Monday 30 October 2017, 10:15 – 11:45
SYMPOSIUM 1: PRECISION MEDICINE AND AUSTRALASIAN DATABASES IN PHARMACOEPIDEMIOLOGY STUDIES
As progress from the Human Genome Project and other precision medicine initiatives around the world continues, a focus on precision medicine in both research and patient care is expanding rapidly. Pharmacoepidemiology is well-placed to make important strides in precision medicine at the population level, thus informing policy makers and regulatory agencies to identify best therapeutic approaches for optimized care. This work could be aided by the development of large biobanks in some Australasian countries that link genetic information with patients’ electronic medical records or associated real world observational data, including China, Korea, Japan, and Australia. These data could also be used to study drug response, or adjunctly to identify and validate drug target genes, and characterize patient’s disease trajectories. Pharmacoepidemiologists using real world evidence have an unparalleled opportunity to contribute to these important projects, and ensure the safest use and effectiveness of drugs in Australasian populations.
Monday 30 October 2017, 15:30 – 17:00
SYMPOSIUM 2: VALIDATION OF LARGE ADMINISTRATIVE DATABASES IN ASIA: METHODOLOGICAL AND PRACTICAL CHALLENGES, AND BEST PRACTICES
Validation studies of administrative healthcare data are critical to allow for the assessment of biases that may be introduced from exposure, confounding and outcome misclassification. While most validation research has been conducted in North America and Europe, a growing body of work validating large databases in Asia has been undertaken in the last 10 years. Nevertheless, validation work brings unique challenges in different territories. This symposium will share methodological and practical issues that confront the researcher when conducting validation studies in Asian countries, focus on common elements across the region and as far as possible, share insights into developing best practices for such studies. The moderators of the session will provide a brief introduction to the scope of research in this area in Asia. Three speakers will discuss examples of validation studies and give country specific perspectives. Finally, a panel discussion led by the moderators with strong audience participation will seek to draw out key themes from across the session.
Tuesday 31 October, 13:30 – 15:00
SYMPOSIUM 3: A NATIONAL APPROACH OF PHARMACOEPIDEMIOLOGIC RESEARCH: THE CANADIAN NETWORK FOR OBSERVATIONAL DRUG EFFECT STUDIES (CNODES)
In 2011, pharmacoepidemiologic research in Canada witnessed a quantum jump with the establishment of the Canadian Network for Observational Drug Effect Studies (CNODES). This pan-Canadian network undertakes distributed analyses of drug safety and effectiveness using nine provincial linked administrative health databases of drug claims, hospitalisations, physician visits, and vital statistics. These analyses are based solely on queries emanating from provincial and federal drug plan decision- and policy-makers. This symposium will describe various facets of the CNODES distributed network, including its mission, relationship with decision- and policy-makers, knowledge translation activities, methods research, training activities, and examples of recent studies.
Tuesday 31 October, 13:30 – 15:00
SYMPOSIUM 4: Post-approval Safety Monitoring and Active Surveillance: Eastern Asia’s perspective
Eastern Asia is a heterogeneous region with different population background on ethnicity, culture, education, and regulations. There are lots of progresses on post-approval research and regulations in this region including continuous safety monitoring, evaluation, and active surveillance. For examples, Japan is exploring the feasibility of using health care databases in addition to traditional survey type of post-marketing safety measures, in understanding further medical product safety in post-approval real world setting. China plans to do additional active surveillance in additional to spontaneous reports. This workshop will invite well known experts in this region to discuss the current status and future direction of research and regulations on post-approval safety monitoring and evaluation in this region.